Piperidinoalkyl derivatives of carboxylic acid amides

Details Piperidinoalkyl derivatives of carboxylic acid amides Piperidinoalkyl derivatives of carboxylic acid amides

C - Chemistry, Metallurgy

07

D

167/211, 260/251

C07D 211/34 (2006.01) A61K 31/445 (2006.01) C07D 211/26 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1339895

The present invention relates to unsaturated carboxylic acid amide derivatives of the formula (see figure I) wherein ring A stands for an optionally substituted aromatic ring; R1 stands for a hydrogen atom or an optionally substituted hydrocarbon residue or forms an optionally substituted carbocyclic ring with the adjacent group -CH=C- together with two carbon atoms constituting the ring A; R2 stands for a hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted acyl group; R3 stands for an optionally substituted hydrocarbon residue; and n denotes an integer ranging from 2 to 6, and salts thereof, as well as the production thereof. The unsaturated carboxylic acid amide derivatives act on the central nervous system of mammals and have a strong anti-cholinesterase activity, and thus can be used for the prophylaxis and therapy of, for example, senile dementia, Alzheimer's diseases, Huntington's chorea, etc., and are useful as medicines.

590959

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