2-amino-5-hydroxy-4-methylpyrimidine derivatives

Details 2-amino-5-hydroxy-4-methylpyrimidine derivatives 2-amino-5-hydroxy-4-methylpyrimidine derivatives

C - Chemistry, Metallurgy

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C07D 239/47 (2006.01) C07D 239/46 (2006.01) C07D 263/48 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)

Patent

CA 1215985

2-AMINO-5-HYDROXY-4-METHYLPYRIMIDINE DERIVATIVES Abstract Novel 2-amino-5-hydroxy-4-methylpyrimidines and substituted amino derivatives thereof useful as inhibi- tors of leukotriene synthesis for the treatment of pulmonary, inflammatory and cardiovascular diseases, cancer and psoriasis. In addition these compounds are cytoprotective and therefore useful in the treatment of peptic ulcers. A process for the preparation of such active compounds by ring rearrangement of 2-amino-5- acetyloxazole, pharmaceutical compositions containing the novel active compounds and compositions containing these compounds in combination with other anti-inflamma- tory agents or gastric anti-secretory agents.

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