C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/264
C07D 237/26 (2006.01) C07D 237/36 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1312864
48 ABSTRACT OF THE DISCLOSURE The invention relates to novel tricyclic derivatiYes which are useful agonists of cholinergic receptors and to drugs containing them. These derivatives have the following formula: Image (I) in which: - X rspxesents a group (CH2)n, n representing an integer equal to 2, 3 or 4, or alternatively a vinylene group or a methylvinylene group; - R1 and R2, considered independently, represent hydrogen or a substituent occupying one of the free positions of the benzene ring and selected from the group comprising halogens, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a thiol group, a nitro group and an optionally substituted amino group: - Y represents oxygen, sulfur or a group -NH-; and - R3 is an amino group, which is - a group Image , in which: ? Alk represents a linear or branched alkylenz group having from 2 to 5 carbon atoms; and ? R4 and R5 each independently represent hydrogen, a lower alkyl grsup or a lower hydroxyalkyl group, or alternatively R4 and R5 forms with the nitrogen atom to which they are bonded, an unsubstituted or lower-alkyl substituted pyrrolidin-l-yl, piperidino, morpholino, piperazin-l-yl or 2-oxo- morphol ino group; 49 - a group -CH2 Image , in which R6 represents; a lower alkyl group having 1 to 4 carbon atoms; or - a group Image , in which R6 is as defined above; and their salts with pharmaceutically acceptable mineral or organic acids.
541127
Biziere Kathleen
Bourguignon Jean J.
Wermuth Camille G.
Worms Paul
Biziere Kathleen
Bourguignon Jean J.
Sim & Mcburney
Societe Anonyme: Sanofi
Wermuth Camille G.
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