Triazolylcyclopropane antifungal agents

C - Chemistry – Metallurgy – 07 – D

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C07D 249/08 (2006.01) A01N 43/653 (2006.01) A61K 31/41 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1276935

Abstract A triazole of the formula:- Image --- (I) where R is a phenyl group optionally substituted by 1 to 3 substituents eacn independently selected from F, Cl, Br, I, CF3, C1-C4 alkyl and C1-C4 alkoxy, or R is a 5-chloropyrid-2-yl group; R1 is a phenyl group optionally substituted by 1 to 3 substituents each independently selected from F, Cl, Br, I, CF3, C1-C4 alkyl and C1-C4 alkoxy; and X is -OH, -F, -Cl or -Br; or an O-ester or O-ether of a compound in which X is -OH; or a pharmaceutically or agriculturally acceptable salt of said compound, ester or ether. The compounds are useful in treating fungal infections in human beings, and as agricultural fungicides.

496087

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