Process for preparing semisynthetic enzymes

Details Process for preparing semisynthetic enzymes Process for preparing semisynthetic enzymes

C - Chemistry, Metallurgy

12

N

195/38, 530/15.0

C12N 9/76 (2006.01) C12N 9/00 (2006.01) C12N 9/16 (2006.01) C12N 9/24 (2006.01) C12N 9/96 (2006.01)

Patent

CA 1177422

ABSTRACT Disclosed is a process for chemically modifying natural- ly occurring proteins to produce biologically active semisynthetic enzymes. The process comprises partially denaturing a protein, then contacting the resulting partially denatured protein with an inhibitor of a model enzyme with the desired biological activ- ity and then cross-linking the protein in situ in the presence of the inhibitor to produce a semisynthetic enzyme having the bio- logical activity of the model enzyme. The thusly prepared semi- synthetic enzyme exhibits different biological activity than the native protein.

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