C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/140, 260/225
C12P 19/04 (2006.01) A61K 31/715 (2006.01) C08B 37/00 (2006.01)
Patent
CA 1239364
- 22 - HYPOTRIGLYCERIDEMICALLY ACTIVE POLYSACCHARIDES ABSTRACT OF THE DISCLOSURE A hypotriglyceridemically active polysaccharide having the following characteristics: (a) Specific rotatory power: [.alpha.]D29= +190.1 (1.8 w/v% solution) (b) Molecular weight by gel filtration: 14,000 ? 3,000 (c) Sugar composition (weight percent by gas chromatography) glucose 70.3 rhamnose 13.7 uronic acid 16.0 (d) Acid-base characteristic: neutral polysaccharides (e) Physiological characteristics: capable of reducing the blood triglyceride in mammals. This hypotriglyceridemically active polysaccharide can be prepared by cultivating a microorganism belonging to the genus Streptococcus in an adequate culture medium therefor; and collecting the hypotriglyceridemically active polysaccharide from the cultured cells of the microorganism and/or the supernatant of the culture broth. The present hypotriglyceridemically active polysaccharide can be used as an active ingredient of a hypotriglyceridemic or antiatherosclerotic pharmaceutical composition together with a pharmaceutically acceptable carrier therefor to form a hypotriglyceridemic or antiatherosclerotic pharmaceutical composition, which is suitable for oral administration to mammals.
458891
Kawai Yasuo
Yazawa Kazunaga
Kabushikikaisya Advance Kaihatsu Kenkyujo
Ridout & Maybee Llp
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