Process for the preparation of pyridazine derivatives having...

Details Process for the preparation of pyridazine derivatives having... Process for the preparation of pyridazine derivatives having...

C - Chemistry, Metallurgy

07

D

260/264.1, 260/2

C07D 237/24 (2006.01) C07D 403/04 (2006.01) C07D 409/04 (2006.01) C07D 413/00 (2006.01) C07D 413/12 (2006.01)

Patent

CA 1218655

PATENT APPLICATION Entitled : Process for the preparation of pyridazine deri- vatives having a psychotropic action, In the names of : Kathleen BIZIERE, Jean-Paul KAN and Camille-Georges WERMUTH. Assignee : Société Anonyme called : SANOFI ABSTRACT The present invention relates to a process for the preparation of 4-cyanopyridazine derivatives cor- responding to the formula below, which consists in treating an appropriately substituted 4-ethoxycarbonyl- pyridazone with aqueous ammonia, in subsequently treating the resulting pyridazone-4-carboxamide with phosphorus oxychloride and in reacting the 3-chloro-4-cyanopyridazine with an amine of the formula H2N-Alk-? Image (I)

445482

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