Process for the synthesis of isosorbide mononitrates

Details Process for the synthesis of isosorbide mononitrates Process for the synthesis of isosorbide mononitrates

C - Chemistry, Metallurgy

07

D

260/361.2

C07D 493/04 (2006.01)

Patent

CA 1182829

Abstract The invention relates to the synthesis of iso- sorbide mononitrates. The process according to the invention consists in reacting a hydrazine derivative with isosorbide dinitrate, in a polar solvent medium. The reaction is preferably carried out at the reflux temperature of the solvent medium, with an excess of the hydrazine derivative. A preferred solvent medium is a mixture of tetrahydrofuran and methanol. The process leads to the preferential formation of isosorbitol-2-mononitrate, which is a coronary vasodilator.

397069

Affiliated with

Also associated with

Rating

Process for the synthesis of isosorbide mononitrates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the synthesis of isosorbide mononitrates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the synthesis of isosorbide mononitrates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1309447