Tetralin esters of phenols or benzoic acids having retinoid...

Details Tetralin esters of phenols or benzoic acids having retinoid... Tetralin esters of phenols or benzoic acids having retinoid...

C - Chemistry, Metallurgy

07

C

167/254, 260/472

C07C 69/773 (2006.01) A61K 31/235 (2006.01) C07C 69/82 (2006.01) C07C 69/90 (2006.01) C07C 235/46 (2006.01)

Patent

CA 1330567

ABSTRACT Retinoid-like activity is exhibited by compounds of the for- mula Image where the R groups are independently hydrogen, or lower alkyl; A is -C(O)O-, -OC(O)-, -C(O)S-, or -SC(O)-; n is 0-5; and Z is H, -COB where B is -OH or a pharmaceutically acceptable salt, or B is -OR1 where R1 is an ester-forming group, or B is -N(R)2 where R is hydrogen or lower alkyl, or Z is -OE where E is hydrogen or an ether-forming group or -COR2 where R2 is hydrogen, lower alkyl, phenyl or lower alkyl phenyl, or Z is -CHO or an acetal derivative thereof, or Z is -COR3 where R3 is -(CH2)mCH3 where m is 0-4 and the sum of n and m does not exceed 4.

596180

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