2-substituted-1-naphthols as 5-lipoxygenase inhibitors

Details 2-substituted-1-naphthols as 5-lipoxygenase inhibitors 2-substituted-1-naphthols as 5-lipoxygenase inhibitors

C - Chemistry, Metallurgy

07

C

167/179, 260/295

C07C 39/38 (2006.01) C07C 39/14 (2006.01) C07C 39/225 (2006.01) C07C 39/23 (2006.01) C07C 43/178 (2006.01) C07C 43/23 (2006.01) C07C 43/295 (2006.01) C07C 59/68 (2006.01) C07C 65/11 (2006.01) C07C 65/24 (2006.01) C07C 69/732 (2006.01) C07C 215/54 (2006.01) C07C 335/32 (2006.01) C07D 213/50 (2006.01) C07D 295/096 (2006.01) C07D 295/185 (2006.01) C07D 307/46 (2006.01) C07D 333/22 (2006.01) C07F 9/40 (2006.01)

Patent

CA 1302417

Title BP-6291-A 2-Substituted-1-Napthols as 5-Lipoxygenase Inhibitors Abstract of the Disclosure 2-Substituted-1-naphthols are 5-lipoxygenase inhibitors which make them useful in the treatment of inflammation, obstructive lung diseases and/or psoriasis. Useful 2-substituent groups are alkyls, alkenyls, alkynyls, cycloalkyls, cycloalkenyls, the the groups CH2-C?C-(CH2)mR5 and CH=CH-(CH2)nR5 (where m is 1-4, n is 0-3 and R5 includes phenyl, COOR9, where R9 is H or alkyl of 1-4 carbons, AR6 (where A is a methylene chain and R6 is a variety of groups including Cl, Br, I, CHO, CN, COOR9, NH2, SC(NH)NH2, phenyl, P(O)(OR9)2, etc.), and CHR7R21 (where R7 is a variety of aromatic and heterocyclic groups and R21 is H, optionally substituted phenyl and a variety of heterocyclic groups).

508534

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