C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.22, 195/1.
C12N 15/29 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07K 14/415 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1340805
A DNA sequence encoding the RIP SO-6 has the sequence: 1 24 50 GTCACATCAATCACATTAGATCTAGTAAATCCGACCGCGGGTCAATACTCATCTTTTGTG 100 GATAAAATCCGAAACAACGTAAAGGATCCAAACCTGAAATACGGTGGTACCGACATAGCC 150 GTGATAGGCCCACCTTCTAAAGAAAAATTCCTTAGAATTAATTTCCAAAGTTCCCGAGGA 200 ACGGTCTCACTTGGCCTAAAACGCGATAACTTGTATGTGGTCGCGTATCTTGCAATGGAT 250 300 AACACGAATGTTAATCGGGCATATTACTTCAGATCAGAAATTACTTCCGCCGAGTCAACC 350 GCCCTTTTCCCAGAGGCCACAACTGCAAATCAGAAAGCTTTAGAATACACAGAAGATTAT 400 CAGTCGATTGAAAAGAATGCCCAGATAACACAAGGAGATCAAAGTAGAAAAGAACTCGGG 450 TTGGGGATTGACTTACTTTCAACGTCCATGGAAGCAGTGAACAAGAAGGCACGTGTGGTT 500 AAAGACGAAGCTAGATTCCTTCTTATCGCTATTCAGATGACGGCTG 550 AGGCAGCGCGATTTAGGTACATACAAAACTTGGTAATCAAGAACTTTCCCAACAAGTTCAA 600 CTCGGAAAACAAAGTGATTCAGTTTGAGGTTAACTGGAAAAAAATTTCTACGGCAATATA 650 700 CGGGGATGCCAAAAACGGCGTGTTTAATAAAGATTATGATTTCGGGTTTGGAAAAGTTAG 750 GCAGGTGAAGGACTTGCAAATGGGACTCCTTATGTATTTGGGCAAACCAAAGTCGTC 768 AAAC. This sequence codes for a ribosomal inactivating protein (RIP) which can be used to inhibit protein synthesis by animal cells. Immunotoxins can be prepared including such an RIP.
603421
Benatti Luca
Dani Maria
Lappi Douglas
Lorenzetti Rolando
Saccardo Maria Beatrice
Farmitalia Carlo Erba S.r.l.
Fetherstonhaugh & Co.
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