Preparation of pyrogen free virus sub-unit vaccines

A - Human Necessities – 61 – K

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A61K 39/145 (2006.01) A61K 39/12 (2006.01)

Patent

CA 1050886

PREPARATION OF PYROGEN FREE VIRUS SUB-UNIT VACCINES ABSTRACT Virus sub-unit vaccines which are substantially free from pyrogens, virion nucleic acids and unwanted antigenic material are prepared by introducing inactivated whole virus into a continuous loading zonal ultracentrifuge provided with a density gradient containing a haemolytic surfactant and banding the split sub-units isopycnically. All ether-sensitive viruses can be used, especially influenza virus.

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