Process for preparing novel azino rifamycins

Details Process for preparing novel azino rifamycins Process for preparing novel azino rifamycins

C - Chemistry, Metallurgy

07

D

260/235.82

C07D 498/08 (2006.01)

Patent

CA 1205074

ABSTRACT OF THE DISCLOSURE There are provided novel azino rifamycin compounds of the formula (I): (I) Image Y=H or CH3CO; R1 linear or branches C1-C7 alkyl or C3-C4 alkenyl- R2=linear or branched C1-C7 alkyl, C2 C4 chloroalkyl, C3-C4 alkenyl, Cycloalkyl having 3 to 7 C atoms in the ring, cycloalkyl alkyl having 3 to 6 C atoms in the ring, phenyl, or C7-C8 aralkyl, unsubstituted or mono-substituted by a halogen atom in the aryl group; or NR1R2 = a cyclic moiety having 5 to 8 C atoms, unsub- stituted or substituted by 1 or 2 CH3 groups, morpholino. The compounds inhibit the growth of gram positive bacteria and myco- bacterium tuberculosis. Oxidized compounds, preparative methods and pharmaceutical compositions are also described and claimed.

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