C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/555.7
C07C 237/00 (2006.01)
Patent
CA 1189535
PROCESS FOR THE PRODUCTION OF CARNITINE AMIDE ABSTRACT OF THE DISCLOSURE Process for the production of carnitine amide in the form of a chloride. The carnitine ethyl ester is obtained by reaction of 4-chloroacetoacetic acid ethyl ester with trimethyl amine and the subsequent hydrogenation is carried out with the help of a Pt/C catalyst. Such carnitine ethyl ester, without isolating it, is reacted with ammonia in an autoclave at -30° to +10°C. Everything is heated to 40° to 80°C. The mixture is stirred at such temperature at an ammoniac pressure of 8 to 24 atu. The product is filtered after cooling it to ambient temperature and counterbalancing the excess pressure. The product is then washed with alcohol and subsequently dried at 30° to 50°C. and at a pressure of 15 to 25 torr.
394670
Blum Rene
Tenud Leander
Hirons & Rogers
Lonza Ltd.
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