Process for the manufacture of aminothiazole acetic acid...

Details Process for the manufacture of aminothiazole acetic acid... Process for the manufacture of aminothiazole acetic acid...

C - Chemistry, Metallurgy

07

D

260/310.5

C07D 277/40 (2006.01) C07D 277/20 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1263399

Abstract There is described a process for the manufacture of a compound of the formula Image IV wherein R1 signifies lower alkyl, lower alkanoyl, lower alkenyl or the group -CH2COOR2 or -C(CH3)2COOR2 and R2 signifies a readily cleavable group, by reacting a compound of the formula Image II wherein R signifies lower alkyl, with an alkali metal allylate and reacting the resulting compound of the formula Image I wherein M signifies an alkali metal atom, with a compound of the formula R1-X, wherein X signifies a leaving group. This process can be used to manufacture antimicrobially active mono-.beta.-lactam, cephalosporin and penicillin derivatives.

495059

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