C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/295, 260/276
C07D 213/54 (2006.01) C07C 51/363 (2006.01) C07D 201/08 (2006.01) C07D 213/26 (2006.01) C07D 213/30 (2006.01) C07D 213/32 (2006.01) C07D 213/50 (2006.01) C07D 213/55 (2006.01) C07D 213/57 (2006.01) C07D 405/06 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01) C07F 9/54 (2006.01)
Patent
CA 1196642
Abstract of the Disclosure Novel compounds of the formula: Image wherein R1 is pyridyl, R2 is phenyl, thienyl, furyl, naphthyl, benzo- thienyl or pyridyl, any of which may be substituted by lower alkoxy, lower alkyl, halogen trifluoromethyl, lower alkenyl or methylenedioxy, R3 is hydrogen or lower alkyl, and n is an integer of 0 to 6, Y is sulphur, methylene or a group of the formula: Image wherein R4 is hydrogen or acetyl, and m is 0 or 1, and their pharmaceutically acceptable salts and acid addition salts are disclosed which inhibit bio- synthesis of thromboxane A2(TXA2) and accelerate the productivity of prostaglandin I2(PGI2), and can be administered to mammals for the prophylaxis or therapy of thrombosis caused by platelet aggregation or ischemic diseases caused by vasospasms in cardiac, cerebral and peripheral circulatory system (e.g. cardiac infarction, apoplexy, infarct of blood vessels in kidney, lung and other organs, pectic ulcer, etc.).
430228
Nishikawa Kohei
Terao Shinji
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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