Membrane-associated proteins (mp.sub.2), a process for...

Details Membrane-associated proteins (mp.sub.2), a process for... Membrane-associated proteins (mp.sub.2), a process for...

C - Chemistry, Metallurgy

07

K

167/113

C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1222693

- 1 - Abstract of the disclosure: Membrane-associated proteins, called MP2, and a process for obtaining them are described. The proteins have the following parameters: a) an electrophoretic mobility in the range between that of ?2 and that of .beta.1 globulins; b) an isoelectric point in the PH range 4.4 - 5.0; c) a sedimentation coefficient s?0W in the range from 7 to above 20 S, the main fractions (IV, III, II and I) sedi- menting at about 7, 9, 14 and 20 S respectively; d) molecular weights in the range from 200,000 to 1,000,000, the main fractions (IV, III, II and I) having molecu- lar weights of about 210,000, 400,000, 750,000 and 1 ,000,000; e) an extinction coefficient E??m (280 nm) of 12.5 ? 0.2; f) a carbohydrate content of 8.0 ? 3.2% (mannose 1.4 ? 0.4%, fucose 0.4 ? 0.2%, galactose 1.2 ? 0.4%, N-acetyl- glucosamine 2.6 ? 1.8%, and N-acetylneuraminic acid 2.4 ? 1.4%) and g) an aminoacid composition in which aspartic acid, glu- tamic acid, leucine, valine, serine and glycine are among the aminoacids present in greatest amounts. These proteins can be used to prepare antisera which can be used to detect and determine these proteins or their components. Furthermore, antibodies reacting - 2 - with these proteins can be used for diagnosis, monitoring the progress of a disease or checking therapy.

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