Acylamino mitosanes

Details Acylamino mitosanes Acylamino mitosanes

C - Chemistry, Metallurgy

07

D

260/299

C07D 487/04 (2006.01) C07D 487/14 (2006.01) C07F 9/24 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 1239645

ABSTRACT 7-Acylamino-9a-methoxymitosanes having enhanced capacity to inhibit animal tumors in vivo relative to mitomycin C are produced by N7-acylation of 7-amino-9a-methoxymitosane, or N1a,N7-diacylation thereof. Carboxamide, thiocarboxamide, urea, thiourea, urethane, thiophosphoramide, phosphoramide, and sulfonamide derivatives are disclosed. These compounds conform to the following formula: Image Formula III wherein R1 is selected from H, C1-6 alkyl, and R7, R7 is selected from Image wherein Ra is selected from H, C1-6 alkyl, A-substituted C1-6 alkyl, C6-10 aryl, A-substituted C6-10 aryl, C7-17 aralkyl, A-substituted C7-17 aralkyl, C2-6 alkenyl, A-substituted C2-6 alkenyl, C2-6 alkynyl, A-substituted C2-6 alkynyl, C3-8 cycloalkyl, C4-10 cycloalkylalkyl, Rb is selected from the group consisting of C1-6 alkyl, A-substituted C1-6 alkyl, C6-10 aryl, A-substituted C6-10 aryl, C7-17 aralkyl and A-substituted C7-17 aralkyl, wherein said A substituent is selected from the group consisting of chlorine, bromine, fluorine, iodine, amino, protected amino, C1-6 alkoxy, C1-6 alkylamino, di(C1-6)alkylamino, C3-8 cycloalkylamino, C4-14 cycloalkylamino, thiol, C1-6 alkylthio, C1-6 alkyldithio, C6-10 arylthio, and C7-17 aralkylthio.

469874

Affiliated with

Also associated with

Rating

Acylamino mitosanes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acylamino mitosanes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acylamino mitosanes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1313276