Esters of hexahydro-8-hydroxy-2, 6-methano-2h-...

Details Esters of hexahydro-8-hydroxy-2, 6-methano-2h-... Esters of hexahydro-8-hydroxy-2, 6-methano-2h-...

C - Chemistry, Metallurgy

07

D

167/211, 260/272

C07D 455/00 (2006.01) A61K 31/435 (2006.01) C07D 471/18 (2006.01)

Patent

CA 1329203

ABSTRACT OF THE DISCLOSURE The present invention is directed to a group of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds. The compounds are prepared from the appro- priate carboxyllc acids and alcohols by standard procedures or, where steric factors are significant, a new process which makes use of heavy metal salts of super acids can be used. The compounds involved are useful in the treatment of migraine and similar disorders and in cytotoxic drug-induced vomiting.

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