Blood coagulation inhibiting proteins, processes for...

A - Human Necessities – 61 – K

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167/114, 167/103

A61K 35/14 (2006.01) A61K 35/44 (2006.01)

Patent

CA 1244763

Abstract Blood coagulation inhibiting proteins, Processes for preparing them and their uses. The present invention relates to anticoagulant proteins, referred to as VAC (Vascular Anti Coagulant) proteins which can be isolated from the walls of blood vessels derived from mammals and which do not inactivate the coagulation factors. These proteins are capable of inhibiting the coagulation induced by a vascular procoagulant or by factor Xa, but cannot inhibit the coagulation induced by thrombin. They do not inhibit the biological and amidolytic activity of factors Xa and IIa.

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