Oxaspiro ¬2,5| octane derivative

Details Oxaspiro ¬2,5| octane derivative Oxaspiro ¬2,5| octane derivative

C - Chemistry, Metallurgy

07

D

167/208, 167/243

C07D 303/44 (2006.01) A61K 31/335 (2006.01) A61K 31/395 (2006.01) C07D 303/22 (2006.01) C07D 405/12 (2006.01) C07D 413/14 (2006.01)

Patent

CA 1340291

There are described oxaspiro[2,5]octane derivatives or salts thereof, more particularly, oxaspiro[2,5]octane derivatives or salts thereof which have an angiogenesis inhibitory activity, and are therefore useful as an angiogenesis inhibitor, especially for the treatment of solid tumors. Processes for the preparation thereof and pharmaceutical compositions comprising the same are also described. The oxaspiro[2,5]octane derivatives are represented by the following formula: (see fig. I) where R1 is an organic radical; R2 is lower alkoxy and R3 is (see fig. II) ; (see fig. III) wherein R6 is a protected carboxy; (see fig. IV) wherein R6 is a protected carboxy; (see fig. v); (see fig. VI) wherein R7 is a protected carboxy(lower)-alkyl or ar(lower)alkyl which may have halogen; or (see fig. VII) wherein R8 ic acyl.

607998

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