Peptides antigonistic to corticotropin releasing factor

Details Peptides antigonistic to corticotropin releasing factor Peptides antigonistic to corticotropin releasing factor

C - Chemistry, Metallurgy

07

K

530/7.1, 530/7.3

C07K 14/575 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1243303

CRF ANTAGONISTS ABSTRACT OF THE DISCLOSURE Several polypeptide analogs of the known members of the corticotropin releasing factor (CRF) family have been synthesized and tested including human and rat CRF which have the formula: Image Peptides are herein disclosed that are potent competitive antagonists of CRF in mammals. One which has been found to be particularly potent is: Image These antagonists or pharmaceutically or veterinarily acceptable salts thereof, dispersed in a pharmaceutically or veterinarily acceptable liquid or solid carrier, can be administered to mammals, including humans, to achieve a prevent elevation of ACTH, .beta.-endorphin, .beta.-lipotropin, other products of the pro-opiomelanocortin gene and corticosterone levels and/or a lowering of brain-mediated responses to stress over an extended period of time. They may also be used to affect mood, memory and learning, as well as diagnostically.

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