Production of 3-allyl- and 3-butenyl-3-cephems

Details Production of 3-allyl- and 3-butenyl-3-cephems Production of 3-allyl- and 3-butenyl-3-cephems

C - Chemistry, Metallurgy

07

D

260/103, 260/108

C07D 501/16 (2006.01) A61K 31/545 (2006.01) C07D 501/04 (2006.01) C07D 501/18 (2006.01) C07D 501/22 (2006.01) C07D 501/24 (2006.01) C07D 501/38 (2006.01) C07D 501/46 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1338644

There is disclosed a process for the production of certain 2-allyl- and 3-butenyl-3-cephem derivatives by coupling a 3-chloromethyl-3-cephem with a hydrocarbyl- tributystannane in the presence of bis(dibenzyl- ideneacetonyl)-palladium and a phosphine. The 3-allyl- and 3-butenyl-3-cephem derivatives so-produced are useful as broad-spectrum antibacterial agents.

564614

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