Process for the preparation of pregnane derivatives

Details Process for the preparation of pregnane derivatives Process for the preparation of pregnane derivatives

C - Chemistry, Metallurgy

07

J

260/37, 260/4, 2

C07J 5/00 (2006.01) C07J 1/00 (2006.01) C07J 7/00 (2006.01) C07J 41/00 (2006.01) C07J 63/00 (2006.01)

Patent

CA 1260929

ABSTRACT OF THE DISCLOSURE Known pregnane derivatives are prepared by esterifica- tion of known androstane derivatives to give new esters of Formula III Image (III), wherein ---- in each case symbolizes a single bond or a double bond, n is 1 or 2, R1 is hydrogen or methyl, R2 is hydrogen or formyl, and R3 is chlorine, hydroxy or an alkkanoyloxy group of up to 6 carbon atoms, and reaction of the latter with Ag(I) and formic acid. The pregnane derivatives so produced are convert- ible by known methods to pharmacological active steroids such as hydrocortisone, 6-alpha-methyl-hydrocortisone, prednisolone or 6- alpha-methyl-prednisolone.

490820

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