Fusion proteins

Details Fusion proteins Fusion proteins

C - Chemistry, Metallurgy

12

N

167/130, 530/15.

C12N 15/62 (2006.01) C07G 99/00 (2009.01) A61K 39/018 (2006.01) A61K 39/145 (2006.01) C07H 21/04 (2006.01) C12N 1/00 (2006.01) C12N 1/19 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/81 (2006.01) C12N 15/86 (2006.01) C12P 19/34 (2006.01) C12P 21/00 (2006.01) A61K 39/12 (2006.01)

Patent

CA 1319629

ABSTRACT A DNA sequence encoding a fusion protein comprising influenza virus HA, at a site of which normally occupied by a natural antigenic epitope thereof a different antigenic epitope is provided, is incorporated in a vector which is capable of expressing the fusion protein when provided in a eucaryotic host. When in the form of a viral vector such as a recombinant vaccinia virus, the vector can be used as a vaccine. Alternatively, the fusion protein expressed by the host can be recovered and provided as a vaccine.

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