Method for rapidly radiolabeling monovalent antibody...

Details Method for rapidly radiolabeling monovalent antibody... Method for rapidly radiolabeling monovalent antibody...

A - Human Necessities

61

K

167/40

A61K 51/10 (2006.01) A61K 51/12 (2006.01)

Patent

CA 1340250

A rapid and quantitative method for producing a sterile, injectable solution of Tc-99m-labeled monovalent antibody fragment comprises the step of mixing a sterile solution containing a monovalent antibody fragment having at least one free sulfhydryl group, stannous chloride and excess tartrate, at mildly acidic pH, or a sucrose-stabilized lyophilizate of such solution, with a sterile solution of Tc-99m-pertechnetate, whereby substantially quantitative labeling of the antibody fragment with Tc-99m is effected in about 5 minutes at ambient temperature, the resultant sterile solution of Tc-99m-labeled monovalent antibody fragment being suitable for immediate injection into a patient for radioimmunodetection.

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