Solid, stable dosage forms with an elastic film coating

A - Human Necessities – 01 – N

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A01N 25/10 (2006.01) A61K 9/28 (2006.01)

Patent

CA 1277238

Solid, stable dosage forms with an elastic film coating Abstract of the Disclosure Solid, stable dosage forms consisting of a moisture- and tempera- ture-sensitive core prepared from a medicament, or a mixture of medicaments, and excipients, and an elastic film coating which decomposes in aqueous solution, said elastic film coating substant- ially comprising a) a water-soluble component consisting of 20 - 60 % of hydroxypropyl cellulose having an average molecular weight of 75,000, and b) a water-insoluble component consisting of 5 - 20 % of an acrylic resin in the form of b1) a 70:30 ethyl acrylate/methyl methacrylate copolymer having a molecular weight of 80,000, or b2) a 30:70 to 70:30 methyl acrylate/methyl methacrylate copolymer having an average molecular weight of 500,000, 20 - 60 % of a lubricant, 0.5 - 5 % of a wetting agent, 0 - 5 % of a plasticiser, and optional additional excipients, and process for the preparation thereof.

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