Sustained release tablets and method for preparation thereof

Details Sustained release tablets and method for preparation thereof Sustained release tablets and method for preparation thereof

A - Human Necessities

61

K

167/166

A61K 9/32 (2006.01) A61K 9/28 (2006.01)

Patent

CA 1251731

ABSTRACT The invention relates to sustained-release pharmaceutical preparations comprising a drug-containing tablet and a coating surrounding the same, wherein the coating is insoluble in water and gastrointestinal fluids and consists essentially of a ter- polymer of polyvinylchloride, polyvinylacetate, and polyvinyl- alcohol and a water-soluble pore-creating substance, the said pore-creating substance being randomly distributed in the ter- polymer coating, the ratio of pore-creating substance to terpolymer being from 1:10 to 20:1 by weight and said pore-creating substance being essentially pharma- cologically inactive in the amount used. The invention also includes a method for the manufacture of the pre- paration.

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