Conjugation of polymer to colony stimulating factor-1

Details Conjugation of polymer to colony stimulating factor-1 Conjugation of polymer to colony stimulating factor-1

C - Chemistry, Metallurgy

07

K

530/13, 530/17.0

C07K 17/08 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) C07K 14/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340297

A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is biologically active and has increased circulating half-life in mammals, compared to that of the unconjugated protein. The conjugated CSF-1 may be used to stimulate the immune response or to provide more cells to be stimulated.

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