Bis-tetrazoylmethyl substituted cephalosporin antibiotics

Details Bis-tetrazoylmethyl substituted cephalosporin antibiotics Bis-tetrazoylmethyl substituted cephalosporin antibiotics

C - Chemistry, Metallurgy

07

D

260/102, 260/103

C07D 501/16 (2006.01) C07D 241/08 (2006.01) C07D 257/04 (2006.01)

Patent

CA 1174668

Abstract 7.beta.-Acylamino-3-cephem-4-carboxylic acids substituted in the 3-position with a bis-tetrazole- methylthiomethyl group and the corresponding 7.alpha.-methoxy cephalosporins represented by the formula Image wherein R is an acyl group, R2 is H or OCH3 and R4 is H or C1-C3 alkyl; are broad spectrum antibiotics useful in the treatment and control of microorganisms patho- genic to man and animals. 7.beta.-Amino nucleus compounds represented when R is hydrogen are intermediates useful in the preparation of the antibiotics where R is acyl.

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