Process for the preparation of a furan derivative

Details Process for the preparation of a furan derivative Process for the preparation of a furan derivative

C - Chemistry, Metallurgy

07

D

260/367.3

C07D 307/52 (2006.01)

Patent

CA 1177490

ABSTRACT Process for the Preparation of a Furan Derivative Ranitidine is preparecl by reacting cystamine of formula (II) Image (II) either with a nitroethenamine of formula (III) Image (III) where L is a leaving group such as alkylthio, e.g. methylthio, or with a compound of formula (IV) (IV) Image where L is a leaving group as defined above, followed by reaction with methylamine, to give a disulphide of formula (V) Image (V) which is then reacted with 5-[(dimethylamino)methyl]-2- furanmethanol under acid conditions.

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