Theophylline sustained release tablet

Details Theophylline sustained release tablet Theophylline sustained release tablet

A - Human Necessities

61

K

167/220

A61K 31/52 (2006.01) A61K 9/20 (2006.01) A61K 9/22 (2006.01)

Patent

CA 1273876

THEOPHYLLINE SUSTAINED RELEASE TABLET Abstract of the Disclosure Compressed tablets from which theophylline is released at a steady rate with twelve hour dosing intervals are disclosed. The tablets contain 43 to 50 weight percent theophylline; 10 to 20 weight percent water insoluble polymer; 10 to 15 weight per- cent of a polymer selected from the group consisting of water soluble polymers and hydrophilic gel formers which swell in wa- ter; and 5 to 15 weight percent acid insoluble polymer having carboxylic groups. The tablet may additionally contain 5 to 9 weight percent hydrophobic lubricant. A preferred composition contains: 43 to 50 weight percent theophylline; 10 to 20 weight percent polyvinyl acetate; 10 to 15 weight percent polyvinylpyrrolidine; 5 to 15 weight percent cellulose acetate phthalate and optionally contains 5 to 7 weight percent of a lubricant mixture containing stearic acid, magnesium stearate and talc.

515271

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