Substituted ethenyl derivatives of 1h-pyrazolo...

Details Substituted ethenyl derivatives of 1h-pyrazolo... Substituted ethenyl derivatives of 1h-pyrazolo...

C - Chemistry, Metallurgy

07

D

260/242.01

C07D 487/04 (2006.01)

Patent

CA 1192547

ABSTRACT The invention relates to novel compounds of general formula (I) Image (I) wherein R1 is: (a) hydrogen or C1-C6 alkyl; (b) a pyridyl group, unsubstituted or substituted by C1-C6 alkyl; (c) a benzyl group, wherein the phenyl ring is unsubstituted or substituted by one or more substituents chosen from halogen, C1 -C6 alkoxy and C1 -C6 alkyl; (d) a phenyl ring, unsubstituted or substituted by one or more substituents chosen from halogen, trihalo-C1 -C6 alkyl, C1 -C6 alkoxy, C1 -C6 alkyl, formylamino, C2 -C6 alkanolamino, nitro and amino; each of R2 and R3 independently represents hydrogen, halogen or C1 -C6 alkyl; R4 represents a pyridyl group, unsubstituted or substituted by C1 -C6 alkyl; or a pharmaceutically acceptable salt thereof. The compounds are active on the gastroenteric system and in particular are endowed with anti- ulcerogenic and gastric anti-secretory activity.

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