C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/187, 260/271
C07D 471/04 (2006.01) A61K 31/44 (2006.01) C07D 463/00 (2006.01)
Patent
CA 1334970
Provided is the crystalline monohydrate of 7.beta.- [2'-(R)-2'-phenyl-2'-aminoacetamido]-3-chloro-3-(1-carba- dethia-cephem)-4-carboxylic acid, of Formula (I): Image (I) and pharmaceutical formulations thereof. The crystalline monohydrate is a valuable antibiotic of superior pharmaceutical elegance which is stable over a wide relative humidity range; it can be prepared from aqueous solutions of the above compound of Formula (I) by adjusting the pH to from 2 to 6.
579158
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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