2-¬4-¬(4,4-dialkyl-2,6-piperidinedion-1-...

Details 2-¬4-¬(4,4-dialkyl-2,6-piperidinedion-1-... 2-¬4-¬(4,4-dialkyl-2,6-piperidinedion-1-...

C - Chemistry, Metallurgy

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D

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C07D 401/14 (2006.01) C07C 51/00 (2006.01) C07D 211/88 (2006.01) C07D 211/90 (2006.01) C07D 239/42 (2006.01) C07D 239/46 (2006.01) C07D 239/56 (2006.01) C07D 309/32 (2006.01) C07D 401/12 (2006.01) C07D 487/10 (2006.01)

Patent

CA 1244426

2-[4-[(4,4-DIALKYL-2,6-PIPERIDINEDION-1-YL) BUTYL]-1-PIPERAZINYL]PYRIMIDINES Abstract of the Disclosure 1-[4-(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]piperazines with 2-pyrimidyl substituents in the 4- position have been synthesized and demonstrate useful anxiolytic properties. The compound 4,4 dimethyl-1-L4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6-piperidinedione, which has selective anxiolytic activity, constitutes the preferred embodiment of the invention. Background of the Invention Related art can be generalized by compounds of the following structural type: Image in which n is 4 or 5 and B is a substituted or unsubstituted 2-pyrimidyl moiety. These and related compounds have been prepared as psychotropic agents and are described in: Wu, et al., Journal of Medicinal Chemistry, 15/5, 477-479 (1972). Wu, et al., U.S. Patent No. 3,717,634 patented Feb. 20, 1973. Wu, et al., U.S. Patent No. 3,907,801 patented Sept. 23, 1975. Wu, et al., U.S. Patent No. 3,976,776 patented Aug, 24, 1976.

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