Method of producing human-human hybridomas, the production...

Details Method of producing human-human hybridomas, the production... Method of producing human-human hybridomas, the production...

C - Chemistry, Metallurgy

07

K

167/139, 195/1.1

C07K 16/30 (2006.01) A61K 39/395 (2006.01) C12N 15/24 (2006.01) C12P 21/08 (2006.01)

Patent

CA 1341552

Human-human hydridomas have been produced by the method of the invention which involves sensitizing human spleen cells with human tumor cells prior to fusion with human fetal marrow, human lymphoblastoid or human plasma cell lines. The monoclonal and polyclonal antibodies produced by the hybridomas disclosed avoid the immune reactions caused by antibodies produced by interspecies hybridomas. IgM and IgA lines have been raised for use against each of the following tumors: colon adenocarcinoma, lung adenocarcinoma, breast adenocarcinoma, mucoepidermoic carcinoma, hepatocellular carcinoma, leiomyosarcoma, melanoma, neurofibrosarcoma, squamous carcinoma of the tongue, squamous carcinoma of the anus, pancreas adenocarcinoma, lymphoblast (acute leukemia), Mycosis Fungoides, oat cell carcinoma, prostate adenocarcinoma, oesophageal squamous carcinoma, Ewing's, gastric adenocarcinoma, biliary adenocarcinoma, ovary adenocarcinoma (mucinous), ovary adenocarcinoma (serous), lymphoblast (lymphoma), alveolar cell carcinoma and glioblastoma.

610944

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