Modulation of lymphokine-resistant cellular states by dsrnas

Details Modulation of lymphokine-resistant cellular states by dsrnas Modulation of lymphokine-resistant cellular states by dsrnas

A - Human Necessities

61

K

167/202, 167/103

A61K 31/70 (2006.01) C07H 21/00 (2006.01)

Patent

CA 1320446

ABSTRACT OF THE DISCLOSURE Tumor cells sub- or non-responding to the antiproliferative effects of lymphokines, notably the interferons and the interleukins, are rendered lymphokine-responsive by exposing the tumor cells to exogenous mismatched dsRNAs. These dsRNAs themselves modulate cell growth of susceptible tumors towards normalization and loss of cancerous cell phenotype.

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