Redox amino acids and peptides containing them

Details Redox amino acids and peptides containing them Redox amino acids and peptides containing them

C - Chemistry, Metallurgy

07

K

530/1, 260/283,

C07K 5/097 (2006.01) C07C 271/22 (2006.01) C07D 211/90 (2006.01) C07D 213/82 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 215/20 (2006.01) C07D 215/233 (2006.01) C07D 215/48 (2006.01) C07K 1/00 (2006.01) C07K 4/00 (2006.01) C07K 5/06 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 5/078 (2006.01) C07K 5/08 (2006.01) C07K 5/087 (2006.01) C07K 5/09 (2006.01) C07K 7/06 (2006.01) C07K 7/23 (2006.01) C07K 14/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340726

The invention provides novel amino acids and peptides containing them which comprise a dihydropyridine ~ pyridinium salt-type redox system and which provide site-specific and sustained delivery of pharmacologically active peptides to the brain. These new amino acids contain a redox system appended directly or via an alkylene bridge to the carbon atom adjacent to the carboxyl carbon and may be incorporated into a peptide chain at a variety of positions, including non-terminal positions.

563439

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