Macrophage stimulation by quadrol

Details Macrophage stimulation by quadrol Macrophage stimulation by quadrol

A - Human Necessities

61

K

167/279, 167/325

A61K 31/13 (2006.01) A61L 15/20 (2006.01) A61L 15/44 (2006.01)

Patent

CA 1313141

ABSTRACT OF THE DISCLOSURE Quadrol and homologs and analogs thereof have been found to stimulate macrophage activity in warm blooded animals. As a consequence, these compounds may be used to combat bacterial infection, remove degenerated tissue, and promote new tissue growth. Quadrol or a homolog or analog thereof may be applied topically, e.g., as the active agent in a wound dressing. The active compounds may be represented by the formula (I) Image wherein R1 and R2 are substituted alkyl (C2- C6) in which the substituents include one or more hydroxyl groups attached to carbon atoms other than the alpha carbon atom, R3 and R4 are alkyl or substituted alkyl (C1-C6), and n=2 to about 6. Preferably R1 through R4 are the same and are 2-hydroxyalkyl.

580310

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