Process for the preparation of penicillanic acid esters

Details Process for the preparation of penicillanic acid esters Process for the preparation of penicillanic acid esters

C - Chemistry, Metallurgy

07

D

260/110, 260/114

C07D 499/00 (2006.01) C07D 499/08 (2006.01) C07D 499/44 (2006.01) C07D 519/00 (2006.01)

Patent

CA 1182107

IMPROVED PROCESS FOR THE PREPARATION OF PENICILLANIC ACID ESTERS Abstract A process for the preparation of chloromethyl esters of penicillanic acids, using iodochloromethane or bromochloromethane and a tetraalkylammonium salt of the penicillanic acid, and their use in processes for the synthesis of penicillanic acid esters, using a halomethyl ester and the tetraalkylammonium salt of the penicillanic acid, which readily hydrolyze in vivo to antibacterial penicillins and the beta-lactamase in- hibitor penicillanic acid sulfone.

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