High titer anti-respiratory syncytial virus intravenous...

Details High titer anti-respiratory syncytial virus intravenous... High titer anti-respiratory syncytial virus intravenous...

C - Chemistry, Metallurgy

07

K

167/139

C07K 16/10 (2006.01) A61K 39/42 (2006.01) G01N 33/535 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1313820

Inventors: MILTON B. DOBKIN Invention: HIGH TITER ANTI-RESPIRATORY SYNCYTIAL VIRUS INTRAVENOUS IMMUNE GLOBULIN Abstract of the Disclosure Normal plasma from donors who have not necessarily been vaccinated with a respiratory syncytial virus vaccine can be screened for higher than normal titers of naturally occurring antibody to respiratory syncytial virus (e.g. minimum ELISA titer of at least 1:110,000). Those plasmas with high titers of such antibody can be pooled and fractionated to give hyperimmune globulin. The product may be treated to render it suitable for intravenous injection. Patients with respiratory syncytial virus infection or at risk of such infection, may receive the present product to raise serum antibody titers to respiratory syncytial virus. Resultant product has an ELISA anti-RSV titer of at least about 1:250,000. CL-125

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