Polypeptide cartilage-inducing factors found in bone

Details Polypeptide cartilage-inducing factors found in bone Polypeptide cartilage-inducing factors found in bone

C - Chemistry, Metallurgy

07

K

530/15.2

C07K 14/495 (2006.01) A61L 27/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1261549

POLYPEPTIDE CARTILAGE-INDUCING FACTORS FOUND IN BONE Abstract Two polypeptide factors that are found in bone and that have chondrogenic/osteogenic activity and TGF- activity are described. Each has a molecular weight of approximately 26,000 daltons by SDS-PAGE. Each reduces to a single polypeptide indicating that the factors are probably homodimers. One has an N-terminal sequence identical to that of human placenta-derived TGF-.beta., whereas the other has an N-terminal sequence that is different from that of TGF-.beta. derived from human placenta. The two factors are purified to homogeneity using RP-HPLC or acetic acid-urea gel electrophoresis.

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