Therapeutic method for treatment of juvenile diabetes...

A - Human Necessities – 61 – K

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167/103.41

A61K 31/205 (2006.01) A61K 31/22 (2006.01)

Patent

CA 1173749

"Therapeutic method for the treatment of juvenile diabetes mellitus and pharmaceutical composition for such a method". ABSTRACT OF THE DISCLOSURES The oral or parenteral administration of L-carnitine or certain L-acyl carnitines, typically L-propionyl carnitine, or the pharmacological salts thereof, permits a considerable reduction (from 20 to approx. 50%) of the daily dose of insulin that should be administered to patients affected by juvenile diabetes mellitus to restore normal blood glucose levels. Moreover, L-carnitine and such acyl carnitines actively inhibit ketoacidosis, thus avoiding the risk of ketoacidosic coma in such patients.

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