Use of amphipathic molecules for radio-imaging and therapy...

Details Use of amphipathic molecules for radio-imaging and therapy... Use of amphipathic molecules for radio-imaging and therapy...

A - Human Necessities

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A61K 39/395 (2006.01) A61K 47/20 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1306194

THE USE OF AMPHIPATHIC MOLECULES FOR RADIOMAGING AND THERAPY WITH CONJUGATES OF MONOCLONAL OR POLYCLONAL ANTIBODIES Abstract of the Disclosure Methods are disclosed for increasing the solubility of antibodies and their radioisotope toxin, or drug immuno- conjugates and for reducing the nonspecific uptake of antibody, either conjugated or unconjugated, into the RES organs such as via Fc receptor-mediated mechanisms. The methods involve incu- bation of the reactive component with amphipathic molecules, such as an anionic detergent, to achieve the desired result. A preferred anionic detergent in this regard is sodium dodecyl- sulfate.

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