Multilamellar liposomes having improved trapping efficiencies

Details Multilamellar liposomes having improved trapping efficiencies Multilamellar liposomes having improved trapping efficiencies

A - Human Necessities

61

K

167/163

A61K 37/22 (1990.01)

Patent

CA 1297014

TLC 118 MULTILAMELLAR LIPOSOMES HAVING IMPROVED TRAPPING EFFICIENCIES ABSTRACT A multilamellar vesicle dispersed in an aqueous phase comprising an aqueous medium, a lipid concentration of at least about 50 mg/ml and a trapping efficiency of at least about 30 percent. The vehicle can be prepared by dispersing the lipid in an aqueous phase to form a multilamellar vesicle, rapidly freezing the multilamellar vesicle to obtain a frozen lipid-aqueous medium mixture, and warming the mixture to obtain a frozen and thawed multilamellar vesicle dispersed in an aqueous phase.

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