Process for the preparation of prolonged-action immunotoxins...

Details Process for the preparation of prolonged-action immunotoxins... Process for the preparation of prolonged-action immunotoxins...

A - Human Necessities

61

K

167/140, 530/15.

A61K 47/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1264667

IN THE CANADIAN PATENT & TRADEMARK OFFICE PATENT APPLICATION entitled: Process for the preparation of prolonged- action immunotoxins containing a glycopeptide constituent which inactivates ribosomes, modified on its poly- saccharide units. in the names of: Franz JANSEN Pierre GROS Assignee: Société anonyme styled: SANOFI ABSTRACT OF THE DISCLOSURE The invention relates to the preparation of prolonged-action immunotoxins consisting of a conjugate in which an antibody or antibody fragment is coupled, by means of a covalent structure containing a disulfide group or a thioether group, with a glycoprotein which inactivates ribosomes and has a prolonged action obtained by the oxidation of its saccharide units with periodate ions.

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