Targeting conjugates of albumin and therapeutic agents

Details Targeting conjugates of albumin and therapeutic agents Targeting conjugates of albumin and therapeutic agents

A - Human Necessities

61

K

167/103, 167/139

A61K 39/395 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1168150

"TARGETING CONJUGATES OF ALBUMIN AND THERAPEUTIC AGENTS" ABSTRACT OF THE DISCLOSURE The invention provides conjugates of a therapeutic agent with carrier albumin and a targeting agent and methods for their preparation. The albumin is included in an amount sufficient to mask antigenicity of the therapeutic agent. The targeting agent used has binding specificity for receptor sites on cells towards which it is desirable to direct the therapeutic agent. Insulin, immunoglobulin G, antibody against human pancreatic tumor cell, and antibody against hyaluronic acid are exemplified as targeting agents.

392658

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