Prolonged release or biologically active polypeptides

A - Human Necessities – 61 – K

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167/103.45

A61K 38/27 (2006.01) A61K 47/00 (2006.01) A61K 47/12 (2006.01) A61K 47/44 (2006.01)

Patent

CA 1309018

37-21(5675) PROLONGED RELEASE OF BIOLOGICALLY ACTIVE POLYPEPTIDES ABSTRACT Prolonged parenteral release of a bioactive polypeptide at desirably effective levels can be achieved using novel compositions in which the poly- peptide is present in a biocompatible oil in an unusually high proportion such as at least about 10% by weight. Also disclosed are certain metal-associated somatotropins that are useful for prolonged parenteral release of such somatotropins.

490016

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