A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/194
A61K 31/56 (2006.01) A61K 9/06 (2006.01) A61K 31/57 (2006.01) A61K 47/14 (2006.01)
Patent
CA 1182048
Abstract Topically administrable pharmaceutical compositions containing anti-inflammatory steroids Pharmaceutical compositions such as ointments and creams are provided by admixture of anti-inflammatory steroids active on topical application with a liquid oily phase containing at least one oil possessing a viscosity less than 10 centistokes and in which the steroid has a solubility of at least 0.5% by weight at 25°C, the degree of unsaturation of the steroid in the liquid oily phase of the composition at 25°C being at least 3. Examples of steroids which may be used are betamethasone, beclomethasone and clobetasol derivatives. Suitable oils include esters of mono- and dibasic aliphatic acids. The compositions may include further oils such as liquid paraffin and conventional additives used in the preparation of ointments and creams. The local anti-inflammatory effect of the steroids is maintained in such formulations but systemic side effects are decreased.
387255
Busse Michael J.
Lees Kenneth A.
Fetherstonhaugh & Co.
Glaxo Group Limited
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