Isoferritin as a marker for pathological pregnancy

Details Isoferritin as a marker for pathological pregnancy Isoferritin as a marker for pathological pregnancy

G - Physics

01

N

167/38

G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1339958

The present invention relates to a method of diagnosis of pathological pregnancy which relies on an evaluation of the amount of placental isoferritin (PLF) in the serum or amniotic fluid of a pregnant woman. Diagnosis may also be achieved by observation of percentages of PLF-bearing lymphocytes in the pregnant female. Detection of PLF-levels is achieved by immunoassay with a PLF-specific antibody. Also described is a method of treating or preventing pathological pregnancies and transplant or graft rejection by administration of effective amounts of PLF and/or a PLF-specific antibody in combination with immunization.

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